CONSIDERATIONS TO KNOW ABOUT XMU-MP-1

Schematic illustration of activated and inhibited Wnt/β-catenin pathway. “WNT ON condition�? Upon ligation of Wnts for their receptors made up of frizzled proteins and LRP5/6, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates to the nucleus and binds to TCF/LEF tran